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Science 19 November 1976:
Vol. 194. no. 4267, pp. 853 - 855
DOI: 10.1126/science.982048
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Articles

Science, Vol 194, Issue 4267, 853-855
Copyright © 1976 by American Association for the Advancement of Science

articles

Calcinogenic factor in Solanum malacoxylon: evidence that it is 1,25-dihydroxyvitamin D3-glycoside

RH Wasserman, JD Henion, MR Haussler, and TA McCain

After glycosidic cleavage of the water-soluble vitamin D-like principle of the calcinogenic plant Solanum malacoxylon, the active lipophilic portion was purified by column chromatography and analyzed by combined gas chromatography and mass spectrometry. It was identified as 1,25-dihydroxyvitamin D3, the active form of vitamin D. Thus this active metabolite of vitamin D exists in the plant world, and its presence probably accounts for pathologic calcification in grazing animals ingesting Solanum malacoxylon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macrophages and Giant Cell Proliferation Associated with Bone Protein Synthesis and Calcification in the Trachea and Bronchi of Rabbits Intoxicated with Solanum glaucophyllum..
S. S. Barros, M. P. Soares, and E. J. Gimeno (2006)
Vet. Pathol. 43, 494-499
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Functional Characterization and Purification of an Intracellular Vitamin D-binding Protein in Vitamin D-resistant New World Primate Cells. AMINO ACID SEQUENCE HOMOLOGY WITH PROTEINS IN THE HSP-70 FAMILY.
M. A. Gacad, H. Chen, J. E. Arbelle, T. LeBon, and J. S. Adams (1997)
J. Biol. Chem. 272, 8433-8440
   Abstract »    Full Text »    PDF »
Experimental diabetes reduces circulating 1,25-dihydroxyvitamin D in the rat.
L. Schneider, H. Schedl, T McCain, and M. Haussler (1977)
Science 196, 1452-1454
   Abstract »    PDF »


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