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Science 12 November 1976:
Vol. 194. no. 4266, pp. 737 - 738
DOI: 10.1126/science.185696
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Articles

Science, Vol 194, Issue 4266, 737-738
Copyright © 1976 by American Association for the Advancement of Science

articles

Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response

WW Busse and J Sosman

Human polymorphonuclear leukocytes treated with cytochalasin B release the lysosomal enzyme beta glucuronidase during contact with serum-activated zymosan particles. Histamine increases intracellular cyclic adenosine monophosphate and inhibits release of this enzyme. The H2 antihistamine metiamide blocks the histamine inhibition of lysosomal enzyme release and the increase in the intracellular adenoisine 3,5'-monophosphate of granulocytes. Chlorpheniramine, an H1 antihistamine, did not block the histamine inhibition of granulocyte lysosomal enzyme release.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bronchial hyperreactivity associated with tracheal gangliosides.
D. Banerjee (1982)
Science 218, 569-571
   Abstract »    PDF »


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