Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 November 1976:
Vol. 194. no. 4266, pp. 737 - 738
DOI: 10.1126/science.185696
Prev | Table of Contents | Next

Articles

Science, Vol 194, Issue 4266, 737-738
Copyright © 1976 by American Association for the Advancement of Science

articles

Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response

WW Busse and J Sosman

Human polymorphonuclear leukocytes treated with cytochalasin B release the lysosomal enzyme beta glucuronidase during contact with serum-activated zymosan particles. Histamine increases intracellular cyclic adenosine monophosphate and inhibits release of this enzyme. The H2 antihistamine metiamide blocks the histamine inhibition of lysosomal enzyme release and the increase in the intracellular adenoisine 3,5'-monophosphate of granulocytes. Chlorpheniramine, an H1 antihistamine, did not block the histamine inhibition of granulocyte lysosomal enzyme release.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bronchial hyperreactivity associated with tracheal gangliosides.
D. Banerjee (1982)
Science 218, 569-571
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)