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Science 12 November 1976:
Vol. 194. no. 4266, pp. 726 - 728
DOI: 10.1126/science.982037
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Articles

Science, Vol 194, Issue 4266, 726-728
Copyright © 1976 by American Association for the Advancement of Science

articles

Stereochemical requirements for intercalation of platinum complexes into double-stranded DNA's

SJ Lippard, PJ Bond, KC WU, and WR Bauer

The complexes 1,10-phenanthrolineethylenediamineplatinum(II) and 2,2'-bipyridineethylenediamineplatinum(II) have a planar, aromatic ligand system that facilitates intercalation, as shown by their ability to unwind closed circular duplex DNA. Nonbonded steric interactions can rotate the pryidine ligands out of the coordination plane in bis(pyridine)ethylenediamineplatinum(II), thus preventing intercalation. Fiber x-ray diffraction patterns of the two metallointeracalators indicate that the binding is governed by the neighbor exclusion principle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metals and DNA: molecular left-handed complements.
J. Barton (1986)
Science 233, 727-734
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)