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Science 5 November 1976:
Vol. 194. no. 4265, pp. 635 - 637
DOI: 10.1126/science.982031
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Articles

Science, Vol 194, Issue 4265, 635-637
Copyright © 1976 by American Association for the Advancement of Science

articles

Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake?

DJ Jenden, RS Jope, and MH Weiler

When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4]acetylcholine. The control of such choline uptake by the cytoplasmic acetylcholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.
E. A. Wehrwein, L. M. Parker, A. A. Wright, J. M. Spitsbergen, M. Novotny, D. Babankova, G. M. Swain, B. A. Habecker, and D. L. Kreulen (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R857-R863
   Abstract »    Full Text »    PDF »
Recognition sites for norepinephrine uptake: regulation by neurotransmitter.
C. Lee, J. Javitch, and S. Snyder (1983)
Science 220, 626-629
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