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Science 5 November 1976:
Vol. 194. no. 4265, pp. 630 - 632
DOI: 10.1126/science.185694
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Articles

Science, Vol 194, Issue 4265, 630-632
Copyright © 1976 by American Association for the Advancement of Science

articles

Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness

F Bloom, D Segal, N Ling, and R Guillemin

The endogenous morphinomimetic brain peptides Met5-enkephalin and alpha-, beta-, and gamma-endorphins have been evaluated in rats after intracerebrospinal fluid injection. beta-Endorphin produces marked, prolonged muscular rigidity and immobility similar to a catatonic state, counteracted by the opiate antagonist naloxone; this effect occurs at molar doses 1/100 to 1/400 that at which the other peptides or morphine block the response to painful stimuli. All peptides evoked dose-related, naloxone-reversible, wet-dog shakes in rats that had not been exposed to drugs. beta-Endorphin produced hypothermia, whereas gamma-endorphin produced hyperthermia. Such potent and divergent responses to naturally occurring subtances suggest that alterations in their homeostatic regulation could have etiological significance in mental illness.


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