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Science 5 November 1976:
Vol. 194. no. 4265, pp. 622 - 624
DOI: 10.1126/science.982030
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Articles

Science, Vol 194, Issue 4265, 622-624
Copyright © 1976 by American Association for the Advancement of Science

articles

Amianthoid change: orientation of normal collagen fibrils during aging

DW Hukins, DP Knight, and J Woodhead-Galloway

High-angle x-ray diffraction provides direct evidence that amianthoid change, occurring during aging of costal cartilage, corresponds to a transformation from an isotropic to a marked anisotropic distribution of collagen fibrils. Low-angle x-ray diffraction and electron microscopy show that the fibrils have the customary 67-nanometer axial periodicity. Electron microscopy shows that wide amianthoid collagen fibrils consist of smaller parallel fibrils fused together. Similarities between amianthoid change and tendon morphogenesis are briefly discussed. Amianthoid change is remarkable in that aging is accompanied by increased order.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure of collagen in cartilage of intervertebral disk.
C Berthet, D. Hulmes, A Miller, and P. Timmins (1978)
Science 199, 547-549
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