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Science 29 October 1976:
Vol. 194. no. 4264, pp. 533 - 535
DOI: 10.1126/science.788154
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Articles

Science, Vol 194, Issue 4264, 533-535
Copyright © 1976 by American Association for the Advancement of Science

articles

Antibacterial synergism: a proposal for chemotherapeutic potentiation between trimethoprim and sulfamethoxazole

M Poe

Sulfamethoxazole and other sulfa drugs are moderately potent inhibitors of Escherichia coli dihydrofolate reductase. They also significantly potentiate the inhibition of this enzyme by trimethoprim. The molecular basis for inhibition potentiation is the simultaneous binding of trimethoprim and sulfa by the enzyme. This potentiation may explain the synergism observed when these drugs are used in antibacterial chemotherapy.


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