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Science 29 October 1976:
Vol. 194. no. 4264, pp. 532 - 533
DOI: 10.1126/science.973137
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Articles

Science, Vol 194, Issue 4264, 532-533
Copyright © 1976 by American Association for the Advancement of Science

articles

Derepressed alloantigen in transplacentally induced lung tumor coded for by H-2 linked gene

WJ Martin, TG Gipson, SE Martin, and JM Rice

A transplacentally induced lung tumor of strain C3Hf mice grows progressively when transplanted to (C3Hf X A)F1 hybrid mice but not when transplanted to C3Hf recipients. Progressive tumor growth occurs in [(C3Hf X A)F1 X C3Hf] backcross mice inheriting the H-2a haplotype from the F1 parent. Furthermore, radioresistant immunity to the lung tumor can be induced in C3Hf mice by immunization with normal tissue of B10.A and B10.A(2R) but not of B10 or B10.A(5R) strain mice.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)