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Science 22 October 1976:
Vol. 194. no. 4263, pp. 442 - 445
DOI: 10.1126/science.824730
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Articles

Science, Vol 194, Issue 4263, 442-445
Copyright © 1976 by American Association for the Advancement of Science

articles

Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency

DH Read, DD Harrington, TW Keenana, and EJ Hinsman

A 9-month-old dog with a history of progressive motor dysfunction was shown to have a deficiency in brain beta-galactosidase activity. The canine disease, like that of children with GM1 gangliosidosis, is characterized by accumulation of GM1 ganglioside in the brain, liver, and spleen, and membranous cytoplasmic bodies in neurons. The dog's pedigree suggests an autosomal recessive pattern of inheritance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
GM1-gangliosidosis in Alaskan Huskies: Clinical and Pathologic Findings.
G. Muller, S. Alldinger, A. Moritz, A. Zurbriggen, N. Kirchhof, A. Sewell, and W. Baumgartner (2001)
Vet. Pathol. 38, 281-290
   Abstract »    Full Text »    PDF »
Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency.
J Alroy, U Orgad, A. Ucci, S. Schelling, K. Schunk, C. Warren, S. Raghavan, and E. Kolodny (1985)
Science 229, 470-472
   Abstract »    PDF »
Mucopolysaccharidosis in a cat with arylsulfatase B deficiency: a model of Maroteaux-Lamy syndrome.
P. Jezyk, M. Haskins, D. Patterson, W. Mellman, and M Greenstein (1977)
Science 198, 834-836
   Abstract »    PDF »


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