Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 October 1976:
Vol. 194. no. 4263, pp. 440 - 442
DOI: 10.1126/science.10625
Prev | Table of Contents | Next

Articles

Science, Vol 194, Issue 4263, 440-442
Copyright © 1976 by American Association for the Advancement of Science

articles

Enkephalin-induced depression of single neurons in brain areas with opiate receptors--antagonism by naloxone

RC Frederickson and FH Norris

Enkephalin, applied microiontophoretically, depressed spontaneous and glutamate-induced firing of single neurons in frontal cortex, caudate nucleus, and periaqueductal gray matter, where enkephalin and high concentrations of opiate receptors are found. Many of the depressions were blocked by the specific narcotic antagonist naloxone. The data are compatible with a neurotransmitter or neuromodulator role for this new brain pentapeptide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Opiate receptor gradients in monkey cerebral cortex: correspondence with sensory processing hierarchies.
M. Lewis, M Mishkin, E Bragin, R. Brown, C. Pert, and A Pert (1981)
Science 211, 1166-1169
   Abstract »    PDF »
Basic and Clinical Studies of Endorphins.
W. E. BUNNEY Jr., C. B. PERT, W. KLEE, E. COSTA, A. PERT, and G. C. DAVIS (1979)
Ann Intern Med 91, 239-250
   Abstract »    PDF »
Peptides in the brain: the new endocrinology of the neuron.
R Guillemin (1978)
Science 202, 390-402
   PDF »
Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication.
J. Barker, J. Neale, T. Smith Jr, and R. Macdonald (1978)
Science 199, 1451-1453
   Abstract »    PDF »
Dual actions of substance P on nociception: possible role of endogenous opioids.
R. Frederickson, V Burgis, C. Harrell, and J. Edwards (1978)
Science 199, 1359-1362
   Abstract »    PDF »
Morphine and enkephalin: analgesic and epileptic properties.
G Urca, H Frenk, J. Liebeskind, and A. Taylor (1977)
Science 197, 83-86
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)