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Science 8 October 1976:
Vol. 194. no. 4261, pp. 195 - 197
DOI: 10.1126/science.785602
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Articles

Science, Vol 194, Issue 4261, 195-197
Copyright © 1976 by American Association for the Advancement of Science

articles

Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital

M Agosin, C Naquira, J Paulin, and J Capdevila

The epimastigotes of Trypanosoma cruzi hydroxylate drugs at substantial rates. The activity, which is of the mixed-function oxidase type, is increased by phenobarbital and is inhibited by CO, SKF 525-A, and metyrapone. The hydroxylation is paralleled by increases in free and membrane-bound ribosomes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet).
R Docampo, S. Moreno, R. Muniz, F. Cruz, and R. Mason (1983)
Science 220, 1292-1295
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