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Science 24 September 1976:
Vol. 193. no. 4259, pp. 1262 - 1263
DOI: 10.1126/science.986687
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Articles

Science, Vol 193, Issue 4259, 1262-1263
Copyright © 1976 by American Association for the Advancement of Science

articles

Physical dependence of opiate-like peptides

E Wei and H Loh

Methionine-enkephalin and beta-endorphin, endogenous peptides with activities similar to those of opiates, were infused for 70 hours into the periaqueductal gray-fourth ventricular space of the rat brain. When challenged with a naloxone, a specific opiate antagonist, these animals manifested a typical morphine-like withdrawal syndrome. These results show that such peptides can cause physical dependence.


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Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine.
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Pharmacol. Rev. 51, 341-396
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Anatomically distinct opiate receptor fields mediate reward and physical dependence.
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Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure.
K Blum, A. Briggs, S. Elston, L DeLallo, P. Sheridan, and M Sar (1982)
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Physical dependence on morphine fails to develop during the hibernating state.
A. Beckman, C Llados-Eckman, T. Stanton, and M. Adler (1981)
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Effect of beta-endorphin on calcium uptake in the brain.
F Guerrero-Munoz, M de Lourdes Guerrero, E. Way, and C. Li (1979)
Science 206, 89-91
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Dual Mechanism Mediating Opiate Effects?.
S. AMIR, R. BLAIR, P. SHIZGAL, and Z. AMIT (1979)
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Dual Mechanism Mediating Opiate Effects?.
Y. F. JACQUET (1979)
Science 205, 425
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Opiate effects after adrenocorticotropin or beta-endorphin injection in the periaqueductal gray matter of rats.
Y. Jacquet (1978)
Science 201, 1032-1034
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Endorphins in Psychiatry: An Overview and a Hypothesis.
K. Verebey, J. Volavka, and D. Clouet (1978)
Arch Gen Psychiatry 35, 877-888
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beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland.
R Guillemin, T Vargo, J Rossier, S Minick, N Ling, C Rivier, W Vale, and F Bloom (1977)
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