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Science 24 September 1976:
Vol. 193. no. 4259, pp. 1260 - 1262
DOI: 10.1126/science.183266
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Articles

Science, Vol 193, Issue 4259, 1260-1262
Copyright © 1976 by American Association for the Advancement of Science

articles

Cytokine inhibition of DNA synthesis: effect on cyclic adenosine monophosphate in lymphocytes

BV Jegasothy, AR Pachner, and BH Waksman

A greater than twofold increase in intracellular adenosine 3',5'-monophosphate (cyclic AMP) inhibited DNA synthesis, in stimulated rat lymphocytes. A two- to fourfold rise of intracellular cyclic AMP, starting at 16 hours, was produced by purified inhibitor od DNA synthesis added to such cells either at 0 or 16 hours, in close association with the initiation of DNA synthesis.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)