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Science 24 September 1976:
Vol. 193. no. 4259, pp. 1245 - 1247
DOI: 10.1126/science.1085490
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Articles

Science, Vol 193, Issue 4259, 1245-1247
Copyright © 1976 by American Association for the Advancement of Science

articles

Multiple sclerosis and high incidence of a B lymphocyte antigen

PI Terasaki, MS Park, G Opelz, and A Ting

Multiple sclerosis patients were tested for six new antigens present on human B lymphocytes. The group 4 specificity occurred in 83.9% of the 56 patients as compared to 32.5 percent in 72 healthy controls (P less than .003). The antiserums defining the five other B lymphocyte specificities reacted at a lower frequency to B cells from multiple sclerosis patients, showing that increased reactivity to group 4 antiserum was specific. Linkage of a hypothesized multiple sclerosis susceptibility gene with certain haplotypes of HLA-A3, HLA-B7 HLA-DW2, and the new B group 4 can be inferred.


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