Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 September 1976:
Vol. 193. no. 4259, pp. 1245 - 1247
DOI: 10.1126/science.1085490
Prev | Table of Contents | Next

Articles

Science, Vol 193, Issue 4259, 1245-1247
Copyright © 1976 by American Association for the Advancement of Science

articles

Multiple sclerosis and high incidence of a B lymphocyte antigen

PI Terasaki, MS Park, G Opelz, and A Ting

Multiple sclerosis patients were tested for six new antigens present on human B lymphocytes. The group 4 specificity occurred in 83.9% of the 56 patients as compared to 32.5 percent in 72 healthy controls (P less than .003). The antiserums defining the five other B lymphocyte specificities reacted at a lower frequency to B cells from multiple sclerosis patients, showing that increased reactivity to group 4 antiserum was specific. Linkage of a hypothesized multiple sclerosis susceptibility gene with certain haplotypes of HLA-A3, HLA-B7 HLA-DW2, and the new B group 4 can be inferred.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The complex genetics of multiple sclerosis: pitfalls and prospects.
S. Sawcer (2008)
Brain 131, 3118-3131
   Abstract »    Full Text »    PDF »
Theiler's Virus Infection: a Model for Multiple Sclerosis.
E. L. Oleszak, J. R. Chang, H. Friedman, C. D. Katsetos, and C. D. Platsoucas (2004)
Clin. Microbiol. Rev. 17, 174-207
   Abstract »    Full Text »    PDF »
Multiple Sclerosis and Affective Disorder: Family History, Sex, and HLA-DR Antigens.
R. B. Schiffer, L. R. Weitkamp, N. M. Wineman, and S. Guttormsen (1988)
Arch Neurol 45, 1345-1348
   Abstract »    PDF »
Primary Sjogren's Syndrome and Other Autoimmune Diseases in Families: Prevalence and lmmunogenetic Studies in Six Kindreds.
J. D. REVEILLE, R. W. WILSON, T. T. PROVOST, W. B. BIAS, and F. C. ARNETT (1984)
Ann Intern Med 101, 748-756
   Abstract »    PDF »
HLA-B14 Antigen and Postencephalitic Parkinson's Disease: Their Association in an American-Jewish Ethnic Group.
T. S. Elizan, P. I. Terasaki, and M. D. Yahr (1980)
Arch Neurol 37, 542-544
   Abstract »    PDF »
Detection of B Cell Antigens in Multiple Sclerosis: Use of Serum From Multiparous Women.
D. E. McFarlin, E. S. Mingioli, T. N. Behar, and H. F. McFarland (1979)
Arch Neurol 36, 819-822
   Abstract »    PDF »
Organization of the immune response genes.
J. Uhr, J. Capra, E. Vitetta, and R. Cook (1979)
Science 206, 292-297
   Abstract »    PDF »
B lymphocyte antigens in sicca syndrome.
H. Moutsopoulos, T. Chused, A. Johnson, B Khudsen, and D. Mann (1978)
Science 199, 1441-1442
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)