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Science 17 September 1976:
Vol. 193. no. 4258, pp. 1131 - 1134
DOI: 10.1126/science.959825
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Articles

Science, Vol 193, Issue 4258, 1131-1134
Copyright © 1976 by American Association for the Advancement of Science

articles

Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen

BB Mandula, MA Pathak, and G Dudek

A compound, 4, 8-dimethyl, 5'-carboxypsoralen (DMeCP), has been identified in mouse urine as a major metabolite of the photoactive drug, 4, 5', 8-trimethylpsoralen (TMeP). This drug is widely used in the treatment of vitiligo and psoriasis. DMeCP is fluorescent, and nonphotosensitizing when tested on guinea pig skin. DMeCP also occurs in the urine of human patients receiving TMeP orally.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig.
A Kornhauser, W. Wamer, and A. Giles Jr (1982)
Science 217, 733-735
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Science. ISSN 0036-8075 (print), 1095-9203 (online)