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Science 17 September 1976:
Vol. 193. no. 4258, pp. 1130 - 1131
DOI: 10.1126/science.959824
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Articles

Science, Vol 193, Issue 4258, 1130-1131
Copyright © 1976 by American Association for the Advancement of Science

articles

Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium

WB Van Winkle

The muscle relaxant dantrolene sodium acts directly and specifically on skeletal muscle, unlike other pharmacological agents which affect the central nervous system or act at the nueromuscular junction. Dantrolene sodium markedly suppresses the release of calcium previously sequestered by skeletal, but not cardiac, muscle sarcoplasmic reticulum. No effect in the total amount of calcium accumulated was found. In situ, the drug may reduce the amount of calcium necessary for muscle contraction.


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