Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 September 1976:
Vol. 193. no. 4258, pp. 1094 - 1100
DOI: 10.1126/science.822515
Prev | Table of Contents | Next

Articles

Science, Vol 193, Issue 4258, 1094-1100
Copyright © 1976 by American Association for the Advancement of Science

articles

Hyperlipidemia and atherosclerosis

R Ross and L Harker

These studies provide new insight into the complex mechanisms wherby hyperlipidemia causes progressive atherosclerosis. It has been shown that physical injury to the endothelial lining of arteries sets off a process which probably is an attempt at healing the injury but which can lead to atherosclerosis. It has also been found that chemical agents such as homocystine can produce a similar series of events leading to atherosclerosis. These events include focal loss of endothelium, exposure of subendothelial connective tissue, and adherence of platelets followed by release of factors that stimulate intimal smooth muscle proliferation. The present studies indicate that the effects of chronic hyperlipidemia are complex in that the condition results not only in the deposition of lipids in the atheromatous lesions but that it may produce the primary endothelial injury that initiates the process of atherosclerosis as well.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Statin Treatment Is Not Associated With Consistent Alterations in Inflammatory Status of Carotid Atherosclerotic Plaques: A Retrospective Study in 378 Patients Undergoing Carotid Endarterectomy.
B. A.N. Verhoeven, F. L. Moll, J. A.F. Koekkoek, A. C. van der Wal, D. P.V. de Kleijn, J. P. P.M. de Vries, J. H. Verheijen, E. Velema, E. Busser, A. Schoneveld, et al. (2006)
Stroke 37, 2054-2060
   Abstract »    Full Text »    PDF »
The anti-inflammatory effect of exercise.
A. M. W. Petersen and B. K. Pedersen (2005)
J Appl Physiol 98, 1154-1162
   Abstract »    Full Text »    PDF »
Heart and mind: (1) relationship between cardiovascular and psychiatric conditions.
S U Shah, A White, S White, and W A Littler (2004)
Postgrad. Med. J. 80, 683-689
   Abstract »    Full Text »    PDF »
Commentary: Insulin Resistance as a Link Between Affective Disorder and Alzheimer's Disease: A Hypothesis in Need of Further Refinement.
C. G. Lyketsos and H. Lee (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, M185-187
   Full Text »    PDF »
Platelet P-selectin facilitates atherosclerotic lesion development.
P. C. Burger and D. D. Wagner (2003)
Blood 101, 2661-2666
   Abstract »    Full Text »    PDF »
Allograft Arteriosclerosis and Immune-Driven Angiogenesis.
P. Libby and D. X.-M. Zhao (2003)
Circulation 107, 1237-1239
   Full Text »    PDF »
Relationship Between Depression and Other Medical Illnesses.
S. P. Roose, A. H. Glassman, and S. N. Seidman (2001)
JAMA 286, 1687-1690
   Full Text »    PDF »
Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor {alpha}1.
P Meerarani, P Ramadass, M. Toborek, H.-C. Bauer, H. Bauer, and B. Hennig (2000)
Am. J. Clinical Nutrition 71, 81-87
   Abstract »    Full Text »    PDF »
Editorials: Lipids and coronary restenosis: an elusive link.
P.J. de Feyter (1999)
Eur. Heart J. 20, 1371-1374
   PDF »
Smoking is Associated with Dose-Related Increase of Intima-Media Thickness and Endothelial Dysfunction.
P. Poredos, M. Orehek, E. Tratnik, and P. Poredos (1999)
Angiology 50, 201-208
   Abstract »    PDF »
Endothelium and acute coronary syndromes.
J. K. Liao (1998)
Clin. Chem. 44, 1799-1808
   Abstract »    Full Text »    PDF »
The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment.
D. L. Musselman, D. L. Evans, and C. B. Nemeroff (1998)
Arch Gen Psychiatry 55, 580-592
   Abstract »    Full Text »    PDF »
Age-Related Changes in Populations of Aortic Glycosaminoglycans : Species With Low Affinity for Plasma Low-Density Lipoproteins, and Not Species With High Affinity, Are Preferentially Affected.
A. M. F. Tovar, D. C. F. Cesar, G. C. Leta, and P. A. S. Mourao (1998)
Arterioscler. Thromb. Vasc. Biol. 18, 604-614
   Abstract »    Full Text »    PDF »
Vitamin E Inhibits Low-Density Lipoprotein–Induced Adhesion of Monocytes to Human Aortic Endothelial Cells In Vitro.
A. Martin, T. Foxall, J. B. Blumberg, and M. Meydani (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 429-436
   Abstract »    Full Text »
Prevention of Hypercholesterolemic Atherosclerosis by Garlic, an Antioxidant.
K. Prasad, S. V. Mantha, J. Kalra, and P. Lee (1997)
Journal of Cardiovascular Pharmacology and Therapeutics 2, 309-319
   Abstract »    PDF »
Early Change of Vascular Permeability in Hypercholesterolemic Rabbits.
C.-C. Wu, S.-W. Chang, M.-S. Chen, and Y.-T. Lee (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 529-533
   Abstract »    Full Text »
Apolipoproteins C-II and C-III in Peripheral Arterial Disease.
C. Alessandri, S. Basili, M. Maurelli, P. Andreozzi, A. Colletta, M. Paradiso, and C. Cordova (1994)
Angiology 45, 131-136
   Abstract »    PDF »
Localization of PDGF-B protein in macrophages in all phases of atherogenesis.
R Ross, J Masuda, E. Raines, A. Gown, S Katsuda, M Sasahara, L. Malden, H Masuko, and H Sato (1990)
Science 248, 1009-1012
   Abstract »    PDF »
Experimental Atherosclerosis and Oxygen Free Radicals.
K. Prasad and J. Kalra (1989)
Angiology 40, 835-843
   Abstract »    PDF »
Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction.
M. A. Austin, J. L. Breslow, C. H. Hennekens, J. E. Buring, W. C. Willett, and R. M. Krauss (1988)
JAMA 260, 1917-1921
   Abstract »    PDF »
Pathogenesis of Atherosclerosis: I: Role of the Nervous System.
J.-s. Yao, J.-f. Wang, H.-y. Li, T.-m. Liu, Wu Giang, and W.-z. Duan (1988)
Angiology 39, 714-719
   Abstract »    PDF »
The Effect of Vegetarian Diets on Plasma Lipid and Platelet Levels.
M. Fisher, P. H. Levine, B. Weiner, I. S. Ockene, B. Johnson, M. H. Johnson, A. M. Natale, C. H. Vaudreuil, and J. Hoogasian (1986)
Arch Intern Med 146, 1193-1197
   Abstract »    PDF »
Arterial Regenerative Activity After Prosthetic Implantation.
H. P. Greisler, D. Un Kim, J. B. Price, and A. B. Voorhees Jr (1985)
Arch Surg 120, 315-323
   Abstract »    PDF »
Arterial Regeneration Over Absorbable Prostheses.
H. P. Greisler (1982)
Arch Surg 117, 1425-1431
   Abstract »    PDF »
Kinetics and Fate of Indium 111 Oxine-Labeled Platelets in Patients With Aortic Aneurysms.
A. duP. Heyns, M. G. Lotter, P. N. Badenhorst, H. Pieters, C. J. C. Nel, and P. C. Minnaar (1982)
Arch Surg 117, 1170-1174
   Abstract »    PDF »
Diet-Induced Arteriopathies in the Rabbit Aorta and Oral Vasculature.
S. Dreizen, M. H. Stern, and B. M. Levy (1978)
Journal of Dental Research 57, 412-417
   Abstract »    PDF »
The Lipid Hypothesis: Pathophysiological Basis.
J. Davignon (1978)
Arch Surg 113, 28-34
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)