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Science 10 September 1976:
Vol. 193. no. 4257, pp. 1007 - 1008
DOI: 10.1126/science.181845

Articles

Science, Vol 193, Issue 4257, 1007-1008
Copyright © 1976 by American Association for the Advancement of Science


articles

Selective in vitro growth of T lymphocytes from normal human bone marrows

DA Morgan, FW Ruscetti, and R Gallo

Selective growth of T lymphocytes occurred when unfractionated normal human bone marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-stimulated normal human lymphocytes (Ly-CM). Cultures of up to 90 percent T cells have been maintained for more than 9 months. The T cells exhibited a strict growth dependence upon Ly-CM and were consistently negative for Epstein-Barr viral information.


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Immune responses in interleukin-2-deficient mice.
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Testing Hypotheses Derived from the Roy Adaptation Model.
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Arch Surg 126, 898-903
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The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application.
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The untold story of HUT78.
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Arch Surg 124, 542-547
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Interleukin-2 in Scleroderma: Correlation of Serum Level with Extent of Skin Involvement and Disease Duration.
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The Hemodynamic Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells.
E. R. Gaynor, L. Vitek, L. Sticklin, S. P. Creekmore, M. E. Ferraro, J. X. Thomas Jr., S. G. Fisher, and R. I. Fisher (1988)
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T. J. Eberlein, D. D. Schoof, S.-E. Jung, D. Davidson, B. Gramolini, K. McGrath, A. Massaro, and R. E. Wilson (1988)
Arch Intern Med 148, 2571-2576
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R. D. Curran, T. R. Billiar, M. A. West, B. G. Bentz, and R. L. Simmons (1988)
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Kaposi's sarcoma cells: long-term culture with growth factor from retrovirus-infected CD4+ T cells.
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New Approaches to the Immunotherapy of Cancer Using Interleukin-2.
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Dermatologic Changes Associated With Interleukin 2 Administration.
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Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders.
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Science 234, 596-601
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Structure-activity studies of interleukin-2.
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Science 234, 349-352
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Immortalization of human T lymphocytes after transfection of Epstein-Barr virus DNA.
M Stevenson, B Volsky, M Hedenskog, and D. Volsky (1986)
Science 233, 980-984
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Regulation of expression of the interleukin-2 receptor on hematopoietic cells by interleukin-3.
M. Birchenall-Sparks, W. Farrar, D Rennick, P. Kilian, and F. Ruscetti (1986)
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The role of mononuclear phagocytes in HTLV-III/LAV infection.
S Gartner, P Markovits, D. Markovitz, M. Kaplan, R. Gallo, and M Popovic (1986)
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The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes.
T. Waldmann (1986)
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Structure of the human interleukin-2 receptor gene.
W. Leonard, J. Depper, M Kanehisa, M Kronke, N. Peffer, P. Svetlik, M Sullivan, and W. Greene (1985)
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A Human T-Lymphotropic Retrovirus (HTLV-III) as the Cause of the Acquired Immunodeficiency Syndrome.
R. C. GALLO and F. WONG-STAAL (1985)
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Science 223, 1086-1087
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Lymphokine production by cultured human T cells transformed by human T-cell leukemia-lymphoma virus-I.
S. Salahuddin, P. Markham, S. Lindner, J Gootenberg, M Popovic, H Hemmi, P. Sarin, and R. Gallo (1984)
Science 223, 703-707
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Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.
L. Seigel, M. Harper, F Wong-Staal, R. Gallo, W. Nash, and S. O'Brien (1984)
Science 223, 175-178
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Human T-Cell Leukemia-Lymphoma Virus and Adult T-Cell Leukemia.
W. A. Blattner, K. Takatsuki, and R. C. Gallo (1983)
JAMA 250, 1074-1080
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Isolation and transmission of human retrovirus (human t-cell leukemia virus).
M Popovic, P. Sarin, M Robert-Gurroff, V. Kalyanaraman, D Mann, J Minowada, and R. Gallo (1983)
Science 219, 856-859
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Continuous lines of basophil/mast cells derived from normal mouse bone marrow.
K Nagao, K Yokoro, and S. Aaronson (1981)
Science 212, 333-335
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Science. ISSN 0036-8075 (print), 1095-9203 (online)