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Science 3 September 1976:
Vol. 193. no. 4256, pp. 897 - 899
DOI: 10.1126/science.7837
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Articles

Science, Vol 193, Issue 4256, 897-899
Copyright © 1976 by American Association for the Advancement of Science

articles

Calcium-independent modulation of cyclic GMP and activation of guanylate cyclase by nitrosamines

FR DeRubertis and PA Craven

Nitrosamines markedly increase concentrations of guanosine 3', 5' - monophosphate (cyclic GMP) in several tissues from the rat and in human colonic mucosa. These agents are effective in the absence of extracellular calcium and enhance guanylate cyclase activity in tissue homogenates. Stimulation of cyclic GMP was greatest in liver, where the carcinogenic activity of nitrosamines is also most pronounced.


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Monitoring Reactions of Nitric Oxide with Peptides and Proteins by Electrospray Ionization-Mass Spectrometry.
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