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Science 20 August 1976:
Vol. 193. no. 4254, pp. 685 - 687
DOI: 10.1126/science.1085034
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Articles

Science, Vol 193, Issue 4254, 685-687
Copyright © 1976 by American Association for the Advancement of Science

articles

Binding of C-reactive protein to antigen-induced but not mitogen-induced T lymphoblasts

SM Croft, RF Mortensen, and H Gewurz

The C-reactive protein (CRP), an acute phase reactant which binds selectively to T (thymus-derived) lymphocytes, was found to bind to lymphoblasts formed upon stimulation with antigens but not with mitogens. Binding of CRP thus serves as a marker for antigen-reactive (-reacted) as opposed to mitogen-reative (-reacted) T cells, suggesting that these represent separate subpopulations, and supports the developing concept that CRP play an important role in the regulation of responses critical to inflammation, host defense, and tissue repair.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Experimental Allergic Encephalomyelitis Is Inhibited in Transgenic Mice Expressing Human C-Reactive Protein.
A. J. Szalai, S. Nataf, X.-Z. Hu, and S. R. Barnum (2002)
J. Immunol. 168, 5792-5797
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