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Science 20 August 1976:
Vol. 193. no. 4254, pp. 681 - 683
DOI: 10.1126/science.821145
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Articles

Science, Vol 193, Issue 4254, 681-683
Copyright © 1976 by American Association for the Advancement of Science

articles

Asparaginase entrapped in red blood cells: action and survival

SJ Updike, RT Wakamiya, and EN Lightfoot Jr

As a strategy to avoid serious allergic reactions to the antitumor agent asparaginase, this enzyme was entrapped in autologous red blood cells before intravenous injection into monkeys. Additional advantages of this approach are prolonged enzyme half-life and targeting of this agent into the reticuloendothelial system.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)