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Science 20 August 1976:
Vol. 193. no. 4254, pp. 673 - 675
DOI: 10.1126/science.781840
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Articles

Science, Vol 193, Issue 4254, 673-675
Copyright © 1976 by American Association for the Advancement of Science

articles

Human malaria parasites in continuous culture

W Trager and JB Jensen

Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen (1 or 5 percent). The original parasite material, derived from an infected Aotus trivirgatus monkey, was diluted more than 100 million times by the addition of human erythrocytes at 3- or 4-day intervals. The parasites continued to reproduce in their normal asexual cycle of approximately 48 hours but were no longer highly synchronous. The have remained infective to Aotus.


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D. F. Echeverry, G. Holmgren, C. Murillo, J. C. Higuita, A. Bjorkman, J. P. Gil, and L. Osorio (2007)
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   Abstract »    Full Text »    PDF »
Use of Biotin Derivatives to Probe Conformational Changes in Proteins.
O. Azim-Zadeh, A. Hillebrecht, U. Linne, M. A. Marahiel, G. Klebe, K. Lingelbach, and J. Nyalwidhe (2007)
J. Biol. Chem. 282, 21609-21617
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Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis.
V. F. de Andrade-Neto, T. da Silva, L. M. X. Lopes, V. E. do Rosario, F. de Pilla Varotti, and A. U. Krettli (2007)
Antimicrob. Agents Chemother. 51, 2346-2350
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Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein 1 of Plasmodium falciparum.
X.-J. Cheng, H. Hayasaka, K. Watanabe, Y.-L. Tao, J.-Y. Liu, H. Tsukamoto, T. Horii, K. Tanabe, and H. Tachibana (2007)
Infect. Immun. 75, 3614-3620
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Inhibition of Dendritic Cell Maturation by Malaria Is Dose Dependent and Does Not Require Plasmodium falciparum Erythrocyte Membrane Protein 1.
S. R. Elliott, T. P. Spurck, J. M. Dodin, A. G. Maier, T. S. Voss, F. Yosaatmadja, P. D. Payne, G. I. McFadden, A. F. Cowman, S. J. Rogerson, et al. (2007)
Infect. Immun. 75, 3621-3632
   Abstract »    Full Text »    PDF »
Neural Cell Adhesion Molecule, a New Cytoadhesion Receptor for Plasmodium falciparum-Infected Erythrocytes Capable of Aggregation.
B. Pouvelle, V. Matarazzo, C. Jurzynski, J. Nemeth, M. Ramharter, G. Rougon, and J. Gysin (2007)
Infect. Immun. 75, 3516-3522
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PfGCN5-Mediated Histone H3 Acetylation Plays a Key Role in Gene Expression in Plasmodium falciparum.
L. Cui, J. Miao, T. Furuya, X. Li, X.-z. Su, and L. Cui (2007)
Eukaryot. Cell 6, 1219-1227
   Abstract »    Full Text »    PDF »
Toward a unifying model of malaria-induced channel activity.
G. Bouyer, S. Egee, and S. L. Y. Thomas (2007)
PNAS 104, 11044-11049
   Abstract »    Full Text »    PDF »
Assessment and Continued Validation of the Malaria SYBR Green I-Based Fluorescence Assay for Use in Malaria Drug Screening.
J. D. Johnson, R. A. Dennull, L. Gerena, M. Lopez-Sanchez, N. E. Roncal, and N. C. Waters (2007)
Antimicrob. Agents Chemother. 51, 1926-1933
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IN VITRO ANTIMALARIAL SUSCEPTIBILITY PROFILE AND PRCRT/PFMDR-1 GENOTYPES OF PLASMODIUM FALCIPARUM FIELD ISOLATES FROM MALAWI.
S. NKHOMA, M. MOLYNEUX, and S. WARD (2007)
Am J Trop Med Hyg 76, 1107-1112
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Cytoadherence and Genotype of Plasmodium falciparum Strains from Symptomatic Children in Franceville, Southeastern Gabon.
F. S. Toure, O. Ouwe-Missi-Oukem-Boyer, J. Mezui-Me-Ndong, G. R. Ndong-Atome, U. Bisvigou, D. Mazier, and S. Bisser (2007)
Clin. Med. Res. 5, 106-113
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Traffic to the Malaria Parasite Food Vacuole: A NOVEL PATHWAY INVOLVING A PHOSPHATIDYLINOSITOL 3-PHOSPHATE-BINDING PROTEIN.
M. T. McIntosh, A. Vaid, H. D. Hosgood, J. Vijay, A. Bhattacharya, M. H. Sahani, P. Baevova, K. A. Joiner, and P. Sharma (2007)
J. Biol. Chem. 282, 11499-11508
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Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.
L. Vivas, L. Rattray, L. B. Stewart, B. L. Robinson, B. Fugmann, R. K. Haynes, W. Peters, and S. L. Croft (2007)
J. Antimicrob. Chemother. 59, 658-665
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Growth Inhibition of Toxoplasma gondii and Plasmodium falciparum by Nanomolar Concentrations of 1-Hydroxy-2-Dodecyl-4(1H)Quinolone, a High-Affinity Inhibitor of Alternative (Type II) NADH Dehydrogenases.
A. Saleh, J. Friesen, S. Baumeister, U. Gross, and W. Bohne (2007)
Antimicrob. Agents Chemother. 51, 1217-1222
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Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes.
F. Benoit-Vical, J. Lelievre, A. Berry, C. Deymier, O. Dechy-Cabaret, J. Cazelles, C. Loup, A. Robert, J.-F. Magnaval, and B. Meunier (2007)
Antimicrob. Agents Chemother. 51, 1463-1472
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Complement Factor D, Albumin, and Immunoglobulin G Anti-Band 3 Protein Antibodies Mimic Serum in Promoting Rosetting of Malaria-Infected Red Blood Cells.
A. Luginbuhl, M. Nikolic, H. P. Beck, M. Wahlgren, and H. U. Lutz (2007)
Infect. Immun. 75, 1771-1777
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Molecular Factors and Biochemical Pathways Induced by Febrile Temperature in Intraerythrocytic Plasmodium falciparum Parasites.
M. S. M. Oakley, S. Kumar, V. Anantharaman, H. Zheng, B. Mahajan, J. D. Haynes, J. K. Moch, R. Fairhurst, T. F. McCutchan, and L. Aravind (2007)
Infect. Immun. 75, 2012-2025
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Fine Mapping of an Epitope Recognized by an Invasion-inhibitory Monoclonal Antibody on the Malaria Vaccine Candidate Apical Membrane Antigen 1.
C. R. Collins, C. Withers-Martinez, G. A. Bentley, A. H. Batchelor, A. W. Thomas, and M. J. Blackman (2007)
J. Biol. Chem. 282, 7431-7441
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15-Deoxyspergualin Primarily Targets the Trafficking of Apicoplast Proteins in Plasmodium falciparum.
T. N. C. Ramya, K. Karmodiya, A. Surolia, and N. Surolia (2007)
J. Biol. Chem. 282, 6388-6397
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ANTIPLASMODIAL INTERACTIONS BETWEEN ARTEMISININ AND TRICLOSAN OR KETOCONAZOLE COMBINATIONS AGAINST BLOOD STAGES OF PLASMODIUM FALCIPARUM IN VITRO.
L. C. MISHRA, A. BHATTACHARYA, and V. K. BHASIN (2007)
Am J Trop Med Hyg 76, 497-501
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A Novel Antibody-Dependent Cellular Cytotoxicity Mechanism Involved in Defense against Malaria Requires Costimulation of Monocytes Fc{gamma}RII and Fc{gamma}RIII.
A. Jafarshad, M. H. Dziegiel, R. Lundquist, L. K. Nielsen, S. Singh, and P. L. Druilhe (2007)
J. Immunol. 178, 3099-3106
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From the Cover: Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.
P. Parroche, F. N. Lauw, N. Goutagny, E. Latz, B. G. Monks, A. Visintin, K. A. Halmen, M. Lamphier, M. Olivier, D. C. Bartholomeu, et al. (2007)
PNAS 104, 1919-1924
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Synergistic Interactions of the Antiretroviral Protease Inhibitors Saquinavir and Ritonavir with Chloroquine and Mefloquine against Plasmodium falciparum In Vitro.
T. S. Skinner-Adams, K. T. Andrews, L. Melville, J. McCarthy, and D. L. Gardiner (2007)
Antimicrob. Agents Chemother. 51, 759-762
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Expression of Merozoite Surface Protein Markers by Plasmodium falciparum-Infected Erythrocytes in Peripheral Blood and Tissues of Children with Fatal Malaria.
C. Dobano, S. J. Rogerson, T. E. Taylor, J. S. McBride, and M. E. Molyneux (2007)
Infect. Immun. 75, 643-652
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