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Science 13 August 1976:
Vol. 193. no. 4253, pp. 599 - 602
DOI: 10.1126/science.959822
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Articles

Science, Vol 193, Issue 4253, 599-602
Copyright © 1976 by American Association for the Advancement of Science

articles

Histones and G banding of chromosomes

GP Holmquist and DE Comings

Polylysine, polyarginine, and histones H1, H2A, H2B, and H3 inhibit Giemsa staining and chromosome banding by binding to DNA and preventing side stacking of the positively charged thiazine dyes to the negatively charged phosphate groups on DNA. This is a nonspecific effect and does not of itself provide evidence for a role of histones in G banding. The question of whether histones are involved in chromosome banding is reviewed.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)