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Science 13 August 1976:
Vol. 193. no. 4253, pp. 595 - 597
DOI: 10.1126/science.959821
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Articles

Science, Vol 193, Issue 4253, 595-597
Copyright © 1976 by American Association for the Advancement of Science

articles

Cytoplasmic aldo-keto reductases: a class of drug metabolizing enzymes

NR Bachur

Aldehyde and ketone xenobiotic substances are preferentially reduced to alcohols by cytoplasmic enzymes in mammals. These enzymes are widely distributed in the tissues, have broad substrate specificities, have similar physical-chemical characteristics, and require reduced nicotinamide adenine dinucleotide as cofactor for the reductions. These reductases define a system of detoxification for aldehyde and ketone groups.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Cloning of a Novel Type of Rat Cytoplasmic 17{beta}-Hydroxysteroid Dehydrogenase Distinct from the Type 5 Isozyme.
S. Ishikura, K. Matsumoto, M. Sanai, K. Horie, T. Matsunaga, K. Tajima, O. El-Kabbani, and A. Hara (2006)
J. Biochem. 139, 1053-1063
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Developmental expression and function of aldehyde reductase in proximal tubules of the kidney.
O. A. Barski, V. Z. Papusha, M. M. Ivanova, D. M. Rudman, and M. J. Finegold (2005)
Am J Physiol Renal Physiol 289, F200-F207
   Abstract »    Full Text »    PDF »
IN VITRO METABOLISM OF THE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR, WORTMANNIN, BY CARBONYL REDUCTASE.
J. L. Holleran, J. Fourcade, M. J. Egorin, J. L. Eiseman, R. A. Parise, S. M. Musser, K. D. White, J. M. Covey, G. L. Forrest, and S.-S. Pan (2004)
Drug Metab. Dispos. 32, 490-496
   Abstract »    Full Text »    PDF »
Human Carbonyl Reductase Overexpression in the Heart Advances the Development of Doxorubicin-induced Cardiotoxicity in Transgenic Mice.
G. L. Forrest, B. Gonzalez, W. Tseng, X. Li, and J. Mann (2000)
Cancer Res. 60, 5158-5164
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