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Science 6 August 1976:
Vol. 193. no. 4252, pp. 510 - 511
DOI: 10.1126/science.181841
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Articles

Science, Vol 193, Issue 4252, 510-511
Copyright © 1976 by American Association for the Advancement of Science

articles

Sustained tolerance to a specific effect of ethanol on posttetanic potentiation in Aplysia

ME Traynor, PB Woodson, WT Schlapfer, and SH Barondes

Perfusion with 0.8 molar ethanol in a seawater specifically accelerates the rate of decay of posttetanic potentiation observed after repetitive electrical stimulation of an identified synapse in the abdominal ganglion of Aplysia californica. Repeated perfusion with seawater alternately with and without ethanol leads to a progressive diminution of this specific effect of ethanol, such that after the third application ethanol no longer has any effect on the rate constant of decay of posttetanic poteniation. This tolerance to the specific effects of ethanol persists for at least 11 hours after the last application of ethanol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.
H Rottenberg, A Waring, and E Rubin (1981)
Science 213, 583-585
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Drug tolerance in biomembranes: a spin label study of the effects of ethanol.
J. Chin and D. Goldstein (1977)
Science 196, 684-685
   Abstract »    PDF »


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