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Science 6 August 1976:
Vol. 193. no. 4252, pp. 493 - 494
DOI: 10.1126/science.941020
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Articles

Science, Vol 193, Issue 4252, 493-494
Copyright © 1976 by American Association for the Advancement of Science

articles

Side chain metabolism of 25-hydroxy-[26,27-14C] vitamin D3 and 1,25-dihydroxy-[26,27-14C] vitamin D3 in vivo

D Harnden, R Kumar, MF Holick, and HF Deluca

Radioactive CO2 was detected in expired air after the administration of 25-hydroxy-[26,27-14C] vitamin d3 to vitamin D-deficient hypocalcemic rats; 14co2 was also detected after the administration of 1,25-dihydroxy-[26,27-14C] vitamin D3 to rats raised on the same diet. Nephretcomy totally abolished 14CO2 formation after administration of 25-hydroxy-[26,27-14C] vitamin D3 but not after the administration of 1,25-dihydroxy-[26,27-14C] vitamin D3. The production of 14CO2 commenced within 4 hours after injection of 1,25-dihydroxy-[26,27-14C] vitamin D3, suggesting a possible relevance of this reaction to the function of 1,25-dihydroxyvitamin D3.These results at least demonstrate a new metabolic pathway of vitamin D3 metabolism involving the oxidation of a portion of the side chain of 1,25-dihydroxyvitamin D3 to CO2.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1{alpha},25-(OH)2D3-26,23-lactone.
D. E. Prosser, M. Kaufmann, B. O'Leary, V. Byford, and G. Jones (2007)
PNAS 104, 12673-12678
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Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.
M. F Holick (2004)
Am. J. Clinical Nutrition 79, 362-371
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Vitamin D Metabolism and Function.
H. F. DeLuca (1978)
Arch Intern Med 138, 836-847
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