Science 30 July 1976: Vol. 193. no. 4251, pp. 415 - 417 DOI: 10.1126/science.180605

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Articles

Enhanced Diabetes-Induced Cataract in Copper-Zinc Superoxide Dismutase-Null Mice.

E. M. Olofsson, S. L. Marklund, and A. Behndig (2009)
Invest. Ophthalmol. Vis. Sci. 50, 2913-2918
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Notch3 and pT{alpha}/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.

A. F. Campese, P. Grazioli, S. Colantoni, E. Anastasi, M. Mecarozzi, S. Checquolo, G. De Luca, D. Bellavia, L. Frati, A. Gulino, et al. (2009)
Int. Immunol. 21, 727-743
 |  Abstract »  |  Full Text »  |  PDF »

Adaptive {beta}-Cell Proliferation Is Severely Restricted With Advanced Age.

M. M. Rankin and J. A. Kushner (2009)
Diabetes 58, 1365-1372
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High {beta}-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

E. Masson, S. Koren, F. Razik, H. Goldberg, E. P. Kwan, L. Sheu, H. Y. Gaisano, and I. G. Fantus (2009)
Am J Physiol Endocrinol Metab 296, E1251-E1261
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In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

K. E. Webster, S. Walters, R. E. Kohler, T. Mrkvan, O. Boyman, C. D. Surh, S. T. Grey, and J. Sprent (2009)
J. Exp. Med. 206, 751-760
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The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.

J. G Mabley, P. Pacher, K. G K Murthy, W. Williams, G. J Southan, A. L Salzman, and C. Szabo (2008)
J. Endocrinol. 198, 581-589
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Streptozocin-Induced Diabetic Mouse Model of Urinary Tract Infection.

D. A. Rosen, C.-S. Hung, K. A. Kline, and S. J. Hultgren (2008)
Infect. Immun. 76, 4290-4298
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Dendritic cells in islets of Langerhans constitutively present {beta} cell-derived peptides bound to their class II MHC molecules.

B. Calderon, A. Suri, M. J. Miller, and E. R. Unanue (2008)
PNAS 105, 6121-6126
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KATP channel-deficient pancreatic {beta}-cells are streptozotocin resistant because of lower GLUT2 activity.

J. Xu, L. Zhang, A. Chou, T. Allaby, G. Belanger, J. Radziuk, B. J. Jasmin, T. Miki, S. Seino, and J.-M. Renaud (2008)
Am J Physiol Endocrinol Metab 294, E326-E335
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Pancreatic Endocrine and Exocrine Cell Ontogeny From Renal Capsule transplanted Embryonic Stem Cells in Streptozocin-injured Mice.

M. Kodama, F. Takeshita, S. Kanegasaki, T. Ochiya, and G. Quinn (2008)
J. Histochem. Cytochem. 56, 33-44
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Mesenchymal Stem Cells Cooperate with Bone Marrow Cells in Therapy of Diabetes.

V. S. Urban, J. Kiss, J. Kovacs, E. Gocza, V. Vas, E. Monostori, and F. Uher (2008)
Stem Cells 26, 244-253
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Role of uncoupling protein UCP2 in cell-mediated immunity: How macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.

Y. Emre, C. Hurtaud, M. Karaca, T. Nubel, F. Zavala, and D. Ricquier (2007)
PNAS 104, 19085-19090
 |  Abstract »  |  Full Text »  |  PDF »

Simvastatin Protects against Multiple Low-Dose Streptozotocin-Induced Type 1 Diabetes in CD-1 Mice and Recurrence of Disease in Nonobese Diabetic Mice.

T. Rydgren, O. Vaarala, and S. Sandler (2007)
J. Pharmacol. Exp. Ther. 323, 180-185
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The Chemokine Binding Protein M3 Prevents Diabetes Induced by Multiple Low Doses of Streptozotocin.

A. P. Martin, J. M. Alexander-Brett, C. Canasto-Chibuque, A. Garin, J. S. Bromberg, D. H. Fremont, and S. A. Lira (2007)
J. Immunol. 178, 4623-4631
 |  Abstract »  |  Full Text »  |  PDF »

A Potent Immunomodulatory Compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole Acetic Acid, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice.

S. Stosic-Grujicic, I. Cvetkovic, K. Mangano, M. Fresta, D. Maksimovic-Ivanic, L. Harhaji, D. Popadic, M. Momcilovic, D. Miljkovic, J. Kim, et al. (2007)
J. Pharmacol. Exp. Ther. 320, 1038-1049
 |  Abstract »  |  Full Text »  |  PDF »

Bone Loss and Increased Bone Adiposity in Spontaneous and Pharmacologically Induced Diabetic Mice.

S. Botolin and L. R. McCabe (2007)
Endocrinology 148, 198-205
 |  Abstract »  |  Full Text »  |  PDF »

STAT5 Activity in Pancreatic {beta}-Cells Influences the Severity of Diabetes in Animal Models of Type 1 and 2 Diabetes..

M. Jackerott, A. Moldrup, P. Thams, E. D. Galsgaard, J. Knudsen, Y. C. Lee, and J. H. Nielsen (2006)
Diabetes 55, 2705-2712
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of Pten in Body Size Determination and Pancreatic {beta}-Cell Homeostasis In Vivo.

K.-T. T. Nguyen, P. Tajmir, C. H. Lin, N. Liadis, X.-D. Zhu, M. Eweida, G. Tolasa-Karaman, F. Cai, R. Wang, T. Kitamura, et al. (2006)
Mol. Cell. Biol. 26, 4511-4518
 |  Abstract »  |  Full Text »  |  PDF »

Hypercholesterolemia Reduces Collateral Artery Growth More Dominantly Than Hyperglycemia or Insulin Resistance in Mice.

V. van Weel, M. de Vries, P. J. Voshol, R. E. Verloop, P. H.C. Eilers, V. W.M. van Hinsbergh, J. H. van Bockel, and P. H.A. Quax (2006)
Arterioscler. Thromb. Vasc. Biol. 26, 1383-1390
 |  Abstract »  |  Full Text »  |  PDF »

Selective Deletion of Pten in Pancreatic {beta} Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes..

B. L. Stiles, C. Kuralwalla-Martinez, W. Guo, C. Gregorian, Y. Wang, J. Tian, M. A. Magnuson, and H. Wu (2006)
Mol. Cell. Biol. 26, 2772-2781
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Elimination of an Endogenous Adjuvant Reduces the Activation of CD8 T Lymphocytes to Transplanted Cells and in an Autoimmune Diabetes Model.

Y. Shi, S. A. Galusha, and K. L. Rock (2006)
J. Immunol. 176, 3905-3908
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic targeting with bone marrow-derived cells and PDGF improves diabetic vascular function.

D. A. Klibansky, A. Chin, I. J. Duignan, and J. M. Edelberg (2006)
Am J Physiol Heart Circ Physiol 290, H1387-H1392
 |  Abstract »  |  Full Text »  |  PDF »

Conditional and specific NF-{kappa}B blockade protects pancreatic beta cells from diabetogenic agents.

R. Eldor, A. Yeffet, K. Baum, V. Doviner, D. Amar, Y. Ben-Neriah, G. Christofori, A. Peled, J. C. Carel, C. Boitard, et al. (2006)
PNAS 103, 5072-5077
 |  Abstract »  |  Full Text »  |  PDF »

Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinopenic diabetes.

E Kim, S Sohn, M Lee, J Jung, R D Kineman, and S Park (2006)
J. Endocrinol. 188, 263-270
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Impact of genetic background on nephropathy in diabetic mice.

S. B. Gurley, S. E. Clare, K. P. Snow, A. Hu, T. W. Meyer, and T. M. Coffman (2006)
Am J Physiol Renal Physiol 290, F214-F222
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Mouse Models and the Genetics of Diabetes: Is There Evidence for Genetic Overlap Between Type 1 and Type 2 Diabetes?.

E. H. Leiter and C.-H. Lee (2005)
Diabetes 54, S151-S158
 |  Abstract »  |  Full Text »  |  PDF »

Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues.

K. M. Thrailkill, C. K. Lumpkin Jr., R. C. Bunn, S. F. Kemp, and J. L. Fowlkes (2005)
Am J Physiol Endocrinol Metab 289, E735-E745
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Very Slow Turnover of {beta}-Cells in Aged Adult Mice.

M. Teta, S. Y. Long, L. M. Wartschow, M. M. Rankin, and J. A. Kushner (2005)
Diabetes 54, 2557-2567
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy.

Z. Qi, H. Fujita, J. Jin, L. S. Davis, Y. Wang, A. B. Fogo, and M. D. Breyer (2005)
Diabetes 54, 2628-2637
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of Macrophage Migration Inhibitory Factor Activity in Experimental Autoimmune Diabetes.

I. Cvetkovic, Y. Al-Abed, D. Miljkovic, D. Maksimovic-Ivanic, J. Roth, M. Bacher, H. Y. Lan, F. Nicoletti, and S. Stosic-Grujicic (2005)
Endocrinology 146, 2942-2951
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-3-Dependent {beta}-Cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus.

N. Liadis, K. Murakami, M. Eweida, A. R. Elford, L. Sheu, H. Y. Gaisano, R. Hakem, P. S. Ohashi, and M. Woo (2005)
Mol. Cell. Biol. 25, 3620-3629
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function.

S.-J. Zheng, S.-E. Lamhamedi-Cherradi, P. Wang, L. Xu, and Y. H. Chen (2005)
Diabetes 54, 1423-1428
 |  Abstract »  |  Full Text »  |  PDF »

Inflammation is More Persistent in Type 1 Diabetic Mice.

D.T. Graves, G. Naguib, H. Lu, C. Leone, H. Hsue, and E. Krall (2005)
Journal of Dental Research 84, 324-328
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue.

C. Kurlawalla-Martinez, B. Stiles, Y. Wang, S. U. Devaskar, B. B. Kahn, and H. Wu (2005)
Mol. Cell. Biol. 25, 2498-2510
 |  Abstract »  |  Full Text »  |  PDF »

Role of lipids in the early developmental stages of experimental immune diabetes induced by multiple low-dose streptozotocin.

D. Pighin, L. Karabatas, C. Pastorale, E. Dascal, C. Carbone, A. Chicco, Y. B. Lombardo, and J. C. Basabe (2005)
J Appl Physiol 98, 1064-1069
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Mouse Models of Diabetic Nephropathy.

M. D. Breyer, E. Bottinger, F. C. Brosius III, T. M. Coffman, R. C. Harris, C. W. Heilig, K. Sharma, and for the AMDCC (2005)
J. Am. Soc. Nephrol. 16, 27-45
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Forebrain Glucose-monitoring Neurons in Taste Information Processing: Electrophysiological and Behavioral Studies.

Z. Karadi, B. Lukats, S. Papp, C. Szalay, R. Egyed, L. Lenard, and G. Takacs (2005)
Chem Senses 30, i168-i169
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Prevention of Spontaneous and Experimentally Induced Diabetes in Mice With Zinc Sulfate-Enriched Drinking Water Is Associated with Activation and Reduction of NF-{kappa}B and AP-1 in Islets, Respectively.

P. Schott-Ohly, A. Lgssiar, H.-J. Partke, M. Hassan, N. Friesen, and H. Gleichmann (2004)
Experimental Biology and Medicine 229, 1177-1185
 |  Abstract »  |  Full Text »  |  PDF »

CD18 Deficiency Protects against Multiple Low-Dose Streptozotocin-Induced Diabetes.

S. C. Barlow, W. Langston, K. M. Matthews, J. H. Chidlow Jr, and C. G. Kevil (2004)
Am. J. Pathol. 165, 1849-1852
 |  Abstract »  |  Full Text »  |  PDF »

RAGE Axis: Animal Models and Novel Insights Into the Vascular Complications of Diabetes.

Y. Naka, L. G. Bucciarelli, T. Wendt, L. K. Lee, L. L. Rong, R. Ramasamy, S. F. Yan, and A. M. Schmidt (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 1342-1349
 |  Abstract »  |  Full Text »  |  PDF »

Role for Activating Transcription Factor 3 in Stress-Induced {beta}-Cell Apoptosis.

M. G. Hartman, D. Lu, M.-L. Kim, G. J. Kociba, T. Shukri, J. Buteau, X. Wang, W. L. Frankel, D. Guttridge, M. Prentki, et al. (2004)
Mol. Cell. Biol. 24, 5721-5732
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-11 Inhibits NF-{kappa}B and AP-1 Activation in Islets and Prevents Diabetes Induced with Streptozotocin in Mice.

A. Lgssiar, M. Hassan, P. Schott-Ohly, N. Friesen, F. Nicoletti, W. L. Trepicchio, and H. Gleichmann (2004)
Experimental Biology and Medicine 229, 425-436
 |  Abstract »  |  Full Text »  |  PDF »

Autoantibodies and CD4 T cells target a {beta} cell retroviral envelope protein in non-obese diabetic mice.

M. G. Levisetti, A. Suri, I. Vidavsky, M. L. Gross, O. Kanagawa, and E. R. Unanue (2003)
Int. Immunol. 15, 1473-1483
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes.

E. Anastasi, A. F. Campese, D. Bellavia, A. Bulotta, A. Balestri, M. Pascucci, S. Checquolo, R. Gradini, U. Lendahl, L. Frati, et al. (2003)
J. Immunol. 171, 4504-4511
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of Type I Diabetes by NF-{kappa}B.

S.-E. Lamhamedi-Cherradi, S. Zheng, B. A. Hilliard, L. Xu, J. Sun, S. Alsheadat, H.-C. Liou, and Y. H. Chen (2003)
J. Immunol. 171, 4886-4892
 |  Abstract »  |  Full Text »  |  PDF »

Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the {beta} cells of islets of Langerhans.

G. Rajagopalan, Y. C. Kudva, L. Chen, L. Wen, and C. S. David (2003)
Int. Immunol. 15, 1035-1044
 |  Abstract »  |  Full Text »  |  PDF »

Critical Roles of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Type 1 Diabetes.

S.-E. Lamhamedi-Cherradi, S. Zheng, R. M. Tisch, and Y. H. Chen (2003)
Diabetes 52, 2274-2278
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes.

R. B. Santana, L. Xu, H. B. Chase, S. Amar, D. T. Graves, and P. C. Trackman (2003)
Diabetes 52, 1502-1510
 |  Abstract »  |  Full Text »  |  PDF »

Human {beta} Cells Are Exceedingly Resistant to Streptozotocin in Vivo.

H. Yang and J. R. Wright Jr (2002)
Endocrinology 143, 2491-2495
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Diabetic Nephropathy in Rats by Prostaglandin E Receptor EP1-Selective Antagonist.

H. Makino, I. Tanaka, M. Mukoyama, A. Sugawara, K. Mori, S. Muro, T. Suganami, K. Yahata, R. Ishibashi, S. Ohuchida, et al. (2002)
J. Am. Soc. Nephrol. 13, 1757-1765
 |  Abstract »  |  Full Text »  |  PDF »

Nicotine Reduces the Incidence of Type I Diabetes in Mice.

J. G. Mabley, P. Pacher, G. J. Southan, A. L. Salzman, and C. Szabo (2002)
J. Pharmacol. Exp. Ther. 300, 876-881
 |  Abstract »  |  Full Text »  |  PDF »

In Situ {beta} Cell Death Promotes Priming of Diabetogenic CD8 T Lymphocytes.

Y. Zhang, B. O'Brien, J. Trudeau, R. Tan, P. Santamaria, and J. P. Dutz (2002)
J. Immunol. 168, 1466-1472
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Transplantable Mouse Renal Cell Cancers by Streptozotocin: In Vivo Growth, Metastases, and Angiogenic Phenotype.

M. E. Gruys, T. C. Back, J. Subleski, T. A. Wiltrout, J.-K. Lee, L. Schmidt, M. Watanabe, R. Stanyon, J. M. Ward, J. M. Wigginton, et al. (2001)
Cancer Res. 61, 6255-6263
 |  Abstract »  |  Full Text »  |  PDF »

Receptor for Advanced Glycation End Products Mediates Inflammation and Enhanced Expression of Tissue Factor in Vasculature of Diabetic Apolipoprotein E-Null Mice.

T. Kislinger, N. Tanji, T. Wendt, W. Qu, Y. Lu, L. J. Ferran Jr, A. Taguchi, K. Olson, L. Bucciarelli, M. Goova, et al. (2001)
Arterioscler. Thromb. Vasc. Biol. 21, 905-910
 |  Abstract »  |  Full Text »  |  PDF »

Low Dose Streptozotocin-Induced Diabetes in Rat Insulin Promoter-mCD80-Transgenic Mice Is T Cell Autoantigen-Specific and CD28 Dependent.

K. Pechhold, N. B. Patterson, C. Blum, C. L. Fleischacker, B. O. Boehm, and D. M. Harlan (2001)
J. Immunol. 166, 2531-2539
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Zinc Supplementation Inhibits NF {{kappa}}B Activation and Protects Against Chemically Induced Diabetes in CD1 Mice.

E. Ho, N. Quan, Y.-H. Tsai, W. Lai, and T. M. Bray (2001)
Experimental Biology and Medicine 226, 103-111
 |  Abstract »  |  Full Text »

The Discovery of Type 1 Diabetes.

E. A.M. Gale (2001)
Diabetes 50, 217-226
 |  Abstract »  |  Full Text »

Islet Blood Flow in Multiple Low Dose Streptozotocin-Treated Wild-Type and Inducible Nitric Oxide Synthase-Deficient Mice.

P.-O. Carlsson, M. Flodstrom, and S. Sandler (2000)
Endocrinology 141, 2752-2757
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of insulitis and diabetes in B cell-deficient mice treated with streptozocin: B cells are essential for the TCR clonotype spreading of islet-infiltrating T cells.

S. Kondo, I. Iwata, K. Anzai, T. Akashi, S. Wakana, K. Ohkubo, H. Katsuta, J. Ono, T. Watanabe, Y. Niho, et al. (2000)
Int. Immunol. 12, 1075-1083
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Pancreatic Islet MHC Class I, Insulin, and ICA 512 Tyrosine Phosphatase in Low-dose Streptozotocin-induced Diabetes in Mice.

Z. Li, L. Zhao, S. Sandler, and F. A. Karlsson (2000)
J. Histochem. Cytochem. 48, 761-768
 |  Abstract »  |  Full Text »

Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: Linkage of O-linked GlcNAc to beta cell death.

K. Liu, A. J. Paterson, E. Chin, and J. E. Kudlow (2000)
PNAS 97, 2820-2825
 |  Abstract »  |  Full Text »  |  PDF »

Evidence from Transgenic Mice That Interferon-beta May Be Involved in the Onset of Diabetes Mellitus.

M. Pelegrin, J. C. Devedjian, C. Costa, J. Visa, G. Solanes, A. Pujol, G. Asins, A. Valera, and F. Bosch (1998)
J. Biol. Chem. 273, 12332-12340
 |  Abstract »  |  Full Text »  |  PDF »

Lymphocyte transfer in streptozotocin-induced diabetes: adhesion of donor cells to islet endothelium.

M. Enghofer, J. Bojunga, R. Ludwig, A. Oldenburg, A. Bernd, K. H. Usadel, and K. Kusterer (1998)
Am J Physiol Endocrinol Metab 274, E928-E935
 |  Abstract »  |  Full Text »  |  PDF »

A Quantitative Cytochemical Study on the Pathogenesis of Streptozotocin-Induced Epithelial Tumors in Rat Kidney.

P. Chieco, A. P. Venturini, M. Barbanti, and E. Romagnoli (1993)
Toxicol Pathol 21, 402-408
 |  Abstract »  |  PDF »

The Role of Chemicals in the Etiology of Diabetes Mellitus.

G. L. Wilson and S. P. LeDoux (1989)
Toxicol Pathol 17, 357-363
 |  Abstract »  |  PDF »

Islet allograft survival after a single course of treatment of recipient with antibody to L3T4.

J. Shizuru, A. Gregory, C. Chao, and C. Fathman (1987)
Science 237, 278-280
 |  Abstract »  |  PDF »

Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.

A. Like, A. Rossini, D. Guberski, M. Appel, and R. Williams (1979)
Science 206, 1421-1423
 |  Abstract »  |  PDF »

Viral and Immunological Bases of Beta Cell Failure in Insulin-Dependent Diabetes.

N. K. Maclaren (1977)
Arch Pediatr Adolesc Med 131, 1149-1154
 |  Abstract »  |  PDF »

Nature and Nurture in the Expression of Diabetes Mellitus and Its Vascular Manifestations.

A. L. Rosenbloom (1977)
Arch Pediatr Adolesc Med 131, 1154-1159
 |  Abstract »  |  PDF »

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