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Science 30 July 1976:
Vol. 193. no. 4251, pp. 412 - 415
DOI: 10.1126/science.180604
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Articles

Science, Vol 193, Issue 4251, 412-415
Copyright © 1976 by American Association for the Advancement of Science

articles

Insulin binding to cultured human fibroblasts increases with normal and precocious aging

AL Rosenbloom, S Goldstein, and CC Yip

Specific and nonspecific [125I]insulin binding and concentration of unlabeled hormone producing 50 percent competition with 1.0 nanomolar [125I]insulin for specific binding sites correlated positively with age of fibroblast donors. Cells from four children with precocious aging--three with progeria and one with Rothmund syndrome-resembled those from the chronologically old.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Progeria.
A. J. Badame (1989)
Arch Dermatol 125, 540-544
   Abstract »    PDF »
Selective display of histamine receptors on lymphocytes.
W Roszkowski, M Plaut, and L. Lichtenstein (1977)
Science 195, 683-685
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)