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Science 30 July 1976:
Vol. 193. no. 4251, pp. 403 - 405
DOI: 10.1126/science.819993
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Articles

Science, Vol 193, Issue 4251, 403-405
Copyright © 1976 by American Association for the Advancement of Science

articles

Thyrotropin releasing hormone: development of inactivation system during maturation of the rat

JT Neary, JD Kieffer, P Federico, H Mover, F Maloof, and M Soodak

Whereas thyrotropin releasing hormone is rapidly and extensively degraded by plasma of adult rats, no appreciable loss of biological or immunological activity is caused by plasma from rats 4 or 16 days old. The plasma of neonatal rats does not appear to contain an inhibitor of thyrotropin releasing hormone peptidase or a peptidase with altered substrate affinity. The development of an active peptidase in rat plasma suggests a physiological role for inactivation of thyrotropin releasing hormone.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)