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Science 23 July 1976:
Vol. 193. no. 4250, pp. 323 - 325
DOI: 10.1126/science.935870
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Articles

Science, Vol 193, Issue 4250, 323-325
Copyright © 1976 by American Association for the Advancement of Science

articles

Morphine analgesic tolerance: its situation specificity supports a Pavlovian conditioning model

S Siegel

Rats were made tolerant to morphine in either of two environments and then assessed for morphine-induced alteration of pain sensitivity in both environments. Analgesic tolerance was displayed when rats were tested in that environment in which they previously received morphine, but not in the alternative environment. The results indicate than an association between environmental cues and the systemic effects of morphine is crucial to tolerance development.


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