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Science 23 July 1976:
Vol. 193. no. 4250, pp. 321 - 323
DOI: 10.1126/science.935869
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Articles

Science, Vol 193, Issue 4250, 321-323
Copyright © 1976 by American Association for the Advancement of Science

articles

Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

SB Baylin, DS Gann, and SH Hsu

A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.


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