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Science 23 July 1976:
Vol. 193. no. 4250, pp. 319 - 321
DOI: 10.1126/science.180600
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Articles

Science, Vol 193, Issue 4250, 319-321
Copyright © 1976 by American Association for the Advancement of Science

articles

Lymphocyte-differentiating hormone of bursa of fabricius

A Brand, DG Gilmour, and G Goldstein

Induction of early lymphocyte differentiation was studied in vitro in fractionated bone marrow cells of newly hatched chickens, with alloantiserums to identify newly differentiated B cells (Bu-1+) and T cells (Th-1+). Thymus extract induced selective T cell differentiation; the activity of the extract corresponds to that of thymopoietin. Bursal extract induced both B cell and T cell differentiation, but at lower concentrations B cell differentiation was always greater. This activity is ascribed to a lymphocyte-differentiating hormone of the bursa of Fabricius, for which the name bursopoietin is suggested.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tripeptide structure of bursin, a selective B-cell-differentiating hormone of the bursa of fabricius.
T Audhya, D Kroon, G Heavner, G Viamontes, and G Goldstein (1986)
Science 231, 997-999
   Abstract »    PDF »
A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin.
G Goldstein, M. Scheid, E. Boyse, D. Schlesinger, and J Van Wauwe (1979)
Science 204, 1309-1310
   Abstract »    PDF »
Thymopoietin and Bursopoietin: Induction Signals Regulating Early Lymphocyte Differentiation.
G. Goldstein, M. Scheid, E. A. Boyse, A. Brand, and D. G. Gilmour (1977)
Cold Spring Harb Symp Quant Biol 41, 5-8
   Abstract »    PDF »


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