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Science 16 July 1976:
Vol. 193. no. 4249, pp. 244 - 246
DOI: 10.1126/science.945613
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Articles

Science, Vol 193, Issue 4249, 244-246
Copyright © 1976 by American Association for the Advancement of Science

articles

Copper supplementation in quaking mutant mice: reduced tremors and increased brain copper

CL Keen and LS Hurley

Mice homozygous for the mutant gene quaking (qk) with a high frequency of axial tremors had a low concentration of copper in the brain. Supplementation during pregnancy and lactation with a high level of dietary copper greatly reduced the frequency of tremors and brought brain copper level to normal in the off-spring. It is suggested that qk affects copper metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation.
J. Piletz and R. Ganschow (1978)
Science 199, 181-183
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