Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 July 1976:
Vol. 193. no. 4249, pp. 237 - 239
DOI: 10.1126/science.935867
Prev | Table of Contents | Next

Articles

Science, Vol 193, Issue 4249, 237-239
Copyright © 1976 by American Association for the Advancement of Science

articles

Fever: effect of drug-induced antipyresis on survival

HA Bernheim and MJ Kluger

To determine whether the prevention of fever affects the survival of an animal infected with pathogenic bacteria, lizards (Dipsosaurus dorsalis) were infected with live Aeromonas hydrophila and received varying doses of sodium salicylate, an antipyretic drug. Twelve lizards received identical injections of bacteria along with a nontoxic dose of sodium salicylate; five animals increased their mean body temperature at least 0.6 degrees C and survived the week, whereas seven did not develop a fever and died within 3 days. These data indicate that in these lizards the prevention of fever by use of an antipyretic drug such as sodium salicylate increases the mortality rate from bacterial infection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Editorial: Hemopexin: newest member of the anti-inflammatory mediator club.
M. P. Fink (2009)
J. Leukoc. Biol. 86, 203-204
   Full Text »    PDF »
Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages.
M. T. Pritchard, Z. Li, and E. A. Repasky (2005)
J. Leukoc. Biol. 78, 630-638
   Abstract »    Full Text »    PDF »
Hypothermia prolongs activation of NF-{kappa}B and augments generation of inflammatory cytokines.
K. D. Fairchild, I. S. Singh, S. Patel, B. E. Drysdale, R. M. Viscardi, L. Hester, H. M. Lazusky, and J. D. Hasday (2004)
Am J Physiol Cell Physiol 287, C422-C431
   Abstract »    Full Text »    PDF »
Physical treatment of fever.
A S EL-RADHI (2000)
Arch. Dis. Child. 83, 369c-369
   Full Text »
Fever in the ICU.
P. E. Marik (2000)
Chest 117, 855-869
   Abstract »    Full Text »    PDF »
Childhood fever: is practice scientific?.
M. Harrison (1998)
J Child Health Care 2, 112-117
   Abstract »    PDF »
Concepts of Fever.
P. A. Mackowiak (1998)
Arch Intern Med 158, 1870-1881
   Abstract »    Full Text »
Fever Revisited.
L. W. Bass (1997)
Arch Pediatr Adolesc Med 151, 647
   Abstract »    PDF »
Antipyresis and Fever.
B. Styrt and B. Sugarman (1990)
Arch Intern Med 150, 1589-1597
   Abstract »    PDF »
The Metabolic Response to Injury and Its Nutritional Implications: Retrospect and Prospect.
D. P. Cuthbertson Sir and H. C. Zagreb Dr. (1979)
JPEN J Parenter Enteral Nutr 3, 108-129
   PDF »
Fever and reduced iron: their interaction as a host defense response to bacterial infection.
M. Kluger and B. Rothenburg (1979)
Science 203, 374-376
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)