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Science 2 July 1976:
Vol. 193. no. 4247, pp. 70 - 72
DOI: 10.1126/science.935859
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Articles

Science, Vol 193, Issue 4247, 70-72
Copyright © 1976 by American Association for the Advancement of Science

articles

Isolations of a cartilage factor that inhibits tumor neovascularization

R Langer, H Brem, K Falterman, M Klein, and J Folkman

A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.


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Ann Intern Med 137, 889-903
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Angioresistance of Thermally Modified Cartilage Grafts in the Chick Chorioallantoic Membrane Model.
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The role of angiogenesis in rheumatoid arthritis: recent developments.
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Ann Rheum Dis 59, i65-71
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Troponin I is present in human cartilage and inhibits angiogenesis.
M. A. Moses, D. Wiederschain, I. Wu, C. A. Fernandez, V. Ghazizadeh, W. S. Lane, E. Flynn, A. Sytkowski, T. Tao, and R. Langer (1999)
PNAS 96, 2645-2650
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The Regulation of Neovascularization by Matrix Metalloproteinases and Their Inhibitors.
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Identification of an inhibitor of neovascularization from cartilage.
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Science 248, 1408-1410
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Vascular Endothelial Cell Growth Inhibitor of Normal and Pathologic Human Vitreous.
B. Jacobson, P. K. Basu, and S. M. Hasany (1984)
Arch Ophthalmol 102, 1543-1545
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Shark cartilage contains inhibitors of tumor angiogenesis.
A Lee and R Langer (1983)
Science 221, 1185-1187
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Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone.
J Folkman, R Langer, R. Linhardt, C Haudenschild, and S Taylor (1983)
Science 221, 719-725
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Angiokines, Angiogenesis and Angiolymphoproliferative Syndromes (ALPS).
S. DeCarvalho (1983)
Angiology 34, 231-243
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Vitreous Inhibition of Tumor Neovascularization.
S. M. Felton, G. C. Brown, N. T. Felberg, and J. L. Federman (1979)
Arch Ophthalmol 97, 1710-1713
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In Vitro Angiogenic Activity of RNA From Leukemic Lymphocytes.
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Angiology 29, 497-505
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Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia.
S. Brem, P. Gullino, and D Medina (1977)
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