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Science 25 June 1976:
Vol. 192. no. 4246, pp. 1357 - 1358
DOI: 10.1126/science.1273597
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Articles

Science, Vol 192, Issue 4246, 1357-1358
Copyright © 1976 by American Association for the Advancement of Science

articles

Analgesia mediated by a direct spinal action of narcotics

TL Yaksh and TA Rudy

Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a chronically inserted catheter produce a potent analgesia that can be antagonized by naloxone. The narcotics, acting only at the spinal level, changed cord function to block not only spinal reflexes but also the operant response to painful stimuli.


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