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Science 25 June 1976:
Vol. 192. no. 4246, pp. 1340 - 1343
DOI: 10.1126/science.1273593
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Articles

Science, Vol 192, Issue 4246, 1340-1343
Copyright © 1976 by American Association for the Advancement of Science

articles

Bone cells in culture: morphologic transformation by hormones

SS Miller, AM Wolf, and CD Arnaud

Hormones and purine nucleosides and nucleotides induced cultured bone cells to transform transiently from a spherical to a stellate shape. Cytochalasin B also induced the transformation. The change was blocked by colchicine and vinblastine, but not by lumicolchicine or cycloheximide. This morphologic transformation may provide a dynamic model of hormone action and bone cell modulation in vitro.


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