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Science 18 June 1976:
Vol. 192. no. 4245, pp. 1249 - 1251
DOI: 10.1126/science.1273591
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Articles

Science, Vol 192, Issue 4245, 1249-1251
Copyright © 1976 by American Association for the Advancement of Science

articles

Residual learning deficit after heavy exposure to cannabis or alcohol in rats

KA Fehr, H Kalant, and AE LeBlanc

Acute oral administration of cannabis extract to rats (tetrahydrocannabinol dose, 10 milligrams per kilogram) impaired maze learning. The impairment was more marked after ten daily doses of the same size. After 1, 2, or 3 months' pretreatment with the same daily dose, followed by a 25-day drug-free period, no residual learning impairment was found. However, 6 months of daily administration of cannabis (tetrahydrocannabinol, 20 milligrams per kilogram) or alcohol (6 grams per kilogram) produced significant residual impairment of learning of maze and motor coordination tasks, 2 months or more after the last drug administration.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Real-world memory and executive processes in cannabis users and non-users.
J. Fisk and C. Montgomery (2008)
J Psychopharmacol 22, 727-736
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Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats.
M. O'Shea, I. S. McGregor, and P. E. Mallet (2006)
J Psychopharmacol 20, 611-621
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Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats.
M. O'Shea, M. E. Singh, I. S. McGregor, and P. E. Mallet (2004)
J Psychopharmacol 18, 502-508
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Hippocampal Neurotoxicity of Delta 9-Tetrahydrocannabinol.
G. C.-K. Chan, T. R. Hinds, S. Impey, and D. R. Storm (1998)
J. Neurosci. 18, 5322-5332
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