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Science 18 June 1976:
Vol. 192. no. 4245, pp. 1238 - 1240
DOI: 10.1126/science.1273589
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Articles

Science, Vol 192, Issue 4245, 1238-1240
Copyright © 1976 by American Association for the Advancement of Science

articles

Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity

SM Michalek, McGhee JR, J Mestecky, RR Arnold, and L Bozzo

Ingestion of killed cells of a highly cariogenic strain of Streptococcus mutans induced specific antibodies in both saliva and milk but not in serum of gnotobiotic rats. These antibodies were associated with the immunoglobulin A class. When infected with Streptococcus mutans, orally immunized animals developed significantly fewer carious lesions than nonimmunized infected controls.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DENTAL CARIES VACCINES: PROSPECTS AND CONCERNS.
D.J. Smith (2002)
Critical Reviews in Oral Biology & Medicine 13, 335-349
   Abstract »    Full Text »    PDF »
An In Vitro Microbial-Caries Model Used to Study the Efficacy of Antibodies to Streptococcus mutans Surface Proteins in Preventing Dental Caries.
M. Fontana, T. L. Buller, A. J. Dunipace, G. K. Stookey, and R. L. Gregory (2000)
Clin. Vaccine Immunol. 7, 49-54
   Abstract »    Full Text »    PDF »
Passive Immunization Against Dental Caries and Periodontal Disease: Development of Recombinant and Human Monoclonal Antibodies.
Y. Abiko (2000)
Critical Reviews in Oral Biology & Medicine 11, 140-158
   Abstract »    Full Text »    PDF »
Intranasal Immunization against Dental Caries with a Streptococcus mutans-Enriched Fimbrial Preparation.
M. Fontana, A. J. Dunipace, G. K. Stookey, and R. L. Gregory (1999)
Clin. Vaccine Immunol. 6, 405-409
   Abstract »    Full Text »    PDF »
Oral Microbial Ecology and the Role of Salivary Immunoglobulin A.
H. Marcotte and M. C. Lavoie (1998)
Microbiol. Mol. Biol. Rev. 62, 71-109
   Abstract »    Full Text »    PDF »
Invited Review: Immunologic Structure and Function of the Gastrointestinal Tract.
B. Langkamp-Henken, J. A. Glezer, and K. A. Kudsk (1992)
Nutr Clin Pract 7, 100-108
   Abstract »    PDF »
Development and Outlook for a Caries Vaccine.
S. M. Michalek and N. K. Childers (1990)
Critical Reviews in Oral Biology & Medicine 1, 37-54
   Full Text »    PDF »
Genetic Analysis of Streptococcus mutans Virulence and Prospects for an Anticaries Vaccine.
R. Curtiss III (1986)
Journal of Dental Research 65, 1034-1045
   PDF »
Immune Dysfunction and Dental Caries: A Preliminary Report.
M.F. Cole, R.R. Arnold, M.J. Rhodes, and J. R. McGhee (1977)
Journal of Dental Research 56, 198-204
   Abstract »    PDF »
Origin and Differentiation of Lymphocytes Involved in the Secretory IgA Response.
J. J. Cebra, P. J. Gearhart, R. Kamat, S. M. Robertson, and J. Tseng (1977)
Cold Spring Harb Symp Quant Biol 41, 201-215
   Abstract »    PDF »


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