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Science 11 June 1976:
Vol. 192. no. 4244, pp. 1134 - 1137
DOI: 10.1126/science.179143
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Articles

Science, Vol 192, Issue 4244, 1134-1137
Copyright © 1976 by American Association for the Advancement of Science

articles

Oncogenic transformation of human embryo lung cells by human cytomegalovirus

KM Geder, R Lausch, F O'Neill, and F Rapp

Persistent infection of human embryo lung fibroblasts with a genital isolate of cytomegalovirus resulted in oncogenic transformation of these cells. Immunofluorescence techniques detected virus-specific antigens, while microcytotoxicity tests established that the transformed cells share a membrane antigen with hamster cells transformed by inactivated cytomegalovirus. The transformed human cells induced progressively growing tumors in weanling athymic nude mice.


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Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection.
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