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Science 4 June 1976:
Vol. 192. no. 4243, pp. 1016 - 1018
DOI: 10.1126/science.775638
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Articles

Science, Vol 192, Issue 4243, 1016-1018
Copyright © 1976 by American Association for the Advancement of Science

articles

Direct evidence for a bone marrow origin of the alveolar macrophage in man

ED Thomas, RE Ramberg, GE Sale, RS Sparkes, and DW Golde

Alveolar macrophages were obtained from 23 patients who had received marrow transplants for hematologic disorders. The presence of a Y body in macrophages of male origin was demonstrated by fluorescence microscopy. In those patients with a marrow donor of opposite sex the alveolar macrophages were shown to be of donor origin. The disappearance with time of host macrophages indicates a life-span, under the conditions, of approximately 81 days.


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