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Science 28 May 1976:
Vol. 192. no. 4242, pp. 910 - 912
DOI: 10.1126/science.5774
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Articles

Science, Vol 192, Issue 4242, 910-912
Copyright © 1976 by American Association for the Advancement of Science

articles

Catecholamine enzymes in the degenerative neurological disease idiopathic orthostatic hypotension

IB Black and CK Petito

Discrete brain areas and sympathetic ganglia obtained at autopsy from patients with idiopathic orthostatic hypotension were assayed for tyrosine hydroxylase and dopamine beta-hydroxylase. Dopamine beta-hydroxylase activity was decreased 7.5-fold in sympathetic ganglia, while tyrosine hydroxylase activity was reduced more than 50-fold in the pontine nucleus locus coeruleus. These observations indicate that noradrenergic neurons of both brain and ganglion are affected in idiopathic orthostatic hypotension, but suggest that the central and peripheral biochemical deficits differ.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Orthostatic Hypotension: I. Functional and Neurogenic Causes.
I. J. Schatz (1984)
Arch Intern Med 144, 773-777
   Abstract »    PDF »
3-Methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in urine of humans with hypertension.
R. Saran, R. Sahuja, N. Gupta, M Hasan, K. Bhargava, K Shanker, and K Kishor (1978)
Science 200, 317-318
   Abstract »    PDF »


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