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Science 28 May 1976:
Vol. 192. no. 4242, pp. 892 - 894
DOI: 10.1126/science.818706
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Articles

Science, Vol 192, Issue 4242, 892-894
Copyright © 1976 by American Association for the Advancement of Science

articles

Hepatocellular transplantation for metabolic deficiencies: decrease of plasms bilirubin in Gunn rats

AJ Matas, DE Sutherland, MW Steffes, SM Mauer, A Sowe, RL Simmons, and JS Najarian

A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme uridine diphosphate glucuronyltransferase following infusion into the portal vein of hepatocytes from heterozygous nonjaundiced Gunn rats possessing the enzyme. Transplantation of cells capable of continuous enzyme production could be an effective mode of therapy for congenital enzyme deficiency diseases.


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Isolated Hepatocyte Transplantation in an Infant With a Severe Urea Cycle Disorder.
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Massive Liver Replacement by Transplanted Hepatocytes in the Absence of Exogenous Growth Stimuli in Rats Treated with Retrorsine.
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Tissue Engineering: Toward New Solutions for Transplantation and Reconstructive Surgery.
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Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes.
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Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation.
S Slavin and S Yatziv (1980)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)