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Science 21 May 1976:
Vol. 192. no. 4241, pp. 805 - 807
DOI: 10.1126/science.1265484

Articles

Science, Vol 192, Issue 4241, 805-807
Copyright © 1976 by American Association for the Advancement of Science


articles

Phytohemagglutinin-induced lymphocyte transformation in humans receiving delta9-tetrahydrocannabinol

RJ Lau, DG Tubergen, M Barr Jr, EF Domino, N Benowitz, and RT Jones

Eight otherwise healthy male chronic marijuana smokers were hospitalized for a period of 30 days. Initially they received placebo, then a sustained dose of 210 milligrams of delta9-tetrahydrocannabinol (delta9-THC) per day for 18 days, followed by placebo. Lymphocyte responses to phytohemagglutinin were examined during each of these periods. Neither the daily ingestion of marijuana extract containing 210 milligrams of delta9-THC for 18 days nor the history of chronic marijuana smoking had a depressive effect on the lymphocyte responses of these subjects to phytohemagglutinin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cannabis, 1977.
D. P. TASHKIN, J. R. SOARES, R. S. HEPLER, B. J. SHAPIRO, and G. S. RACHELEFSKY (1978)
Ann Intern Med 89, 539-549
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