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Science 21 May 1976:
Vol. 192. no. 4241, pp. 803 - 805
DOI: 10.1126/science.178053
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Articles

Science, Vol 192, Issue 4241, 803-805
Copyright © 1976 by American Association for the Advancement of Science

articles

Cholera toxin induces pineal enzymes in culture

KP Minneman and LL Iversen

Addition of choleragen to rat pineal organ cultures caused a long-lasting stimulation of adenylate cyclase activity, and this was followed by increases in seroton N-acetyltransferase and cyclic adenosine monophosphate phosphodiesterase activities. These effects of choleragen were not blocked by the beta-adrenoceptor antagonist propranolol, but the increases in cyclic adenosine monophosphate phosphodiesterase and serotonin N-acetyltransferase activities could be prevented by the protein synthesis inhibitor cycloheximide. The results indicate that cholera toxin can mimic the induction of pineal enzymes that normally follows beta-adrenoceptor activation and suggest that increased cyclic adenosine monophosphate is a necessary and sufficient signal for such changes in enzyme activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pineal serotonin N-acetyltransferase activity: abrupt decrease in adenosine 3',5'-monophosphate may be signal for "turnoff".
D. Klein, M. Buda, C. Kapoor, and G Krishna (1978)
Science 199, 309-311
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