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Science 21 May 1976:
Vol. 192. no. 4241, pp. 796 - 798
DOI: 10.1126/science.1265482
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Articles

Science, Vol 192, Issue 4241, 796-798
Copyright © 1976 by American Association for the Advancement of Science

articles

DNA structure in sheared and unsheared chromatin

C Nicolini, R Baserga, and F Kendall

Shearing chromatin, by either sonication or vortex homogenization, introduces significant structural artifacts. These may be detected by the anomalously large increase in the number of ethidium bromide binding sites and the large alteration of the circular dichroism spectra of chromatin. Structural alterations are also suggested by the disappearance of differential light scattering after shearing.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear morphometry during the cell cycle.
F Kendall, R Swenson, T Borun, J Rowinski, and C Nicolini (1977)
Science 196, 1106-1109
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Science. ISSN 0036-8075 (print), 1095-9203 (online)