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Science 21 May 1976:
Vol. 192. no. 4241, pp. 783 - 784
DOI: 10.1126/science.1265479
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Articles

Science, Vol 192, Issue 4241, 783-784
Copyright © 1976 by American Association for the Advancement of Science

articles

Gating currents associated with sodium and calcium currents in an Aplysia neuron

DJ Adams and PW Gage

In a voltage-clamped aplysia neuron (R15), depolarization beyond -30 millivolts produces an inward sodium current. Depolarization beyond -10 millivolts produces an additional inward calcium current with slower kinetics than the sodium current. When these ionic currents have been suppressed and capacitive currents subtracted out, a small outward displacement current can be seen with depolarizations beyond -30 millivolts. An additional, slower displacement current is seen with depolarizations beyond -10 millivolts. The currents have an exponential decay with an increase in rate per 10 degrees C increase in temperature of about 3 and are thought to be sodium and calcium gating currents.


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