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Science 30 April 1976:
Vol. 192. no. 4238, pp. 469 - 471
DOI: 10.1126/science.3853
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Articles

Science, Vol 192, Issue 4238, 469-471
Copyright © 1976 by American Association for the Advancement of Science

articles

Antibodies to histones and histone-histone complexes: immunochemical evidence for secondary structure in histone 1

N Mihalakis, OJ Miller, and BF Erlanger

Highly specific antibodies were raised to histone 1 (H 1) and the histone complexes H32-H42 AND H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in acid- or urea-treated H1. The antibodies showed different reactivities with chromosomes as compared to antibodies in acid-extracted histones and should be useful in studies of native chromatin and chromosome structure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunochemical Studies on the 5-Methylcytosine Content of African Green Monkey Satellite DNA.
Z. E. Kahana, O. J. Miller, and B. F. Erlanger (1978)
Cold Spring Harb Symp Quant Biol 42, 397-400
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Science. ISSN 0036-8075 (print), 1095-9203 (online)