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Science 23 April 1976:
Vol. 192. no. 4237, pp. 391 - 393
DOI: 10.1126/science.1257777
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Articles

Science, Vol 192, Issue 4237, 391-393
Copyright © 1976 by American Association for the Advancement of Science

articles

d-Amphetamine-induced inhibition of central dopaminergic neurons: mediation by a striato-nigral feedback pathway

BS Bunney and GK Achajanian

Lesions of the striato-nigral pathways (that is, crus cerebri or vicinity of the tail of the caudate nucleus) markedly attenuate depressant effects of intravenous d-amphetamine on central dopaminergic cell activity. These results, coupled with previous data showing that microiontophoretic application of d-amphetamine directly onto dopaminergic cells does not produce significant slowing, provide direct support for the hypothesis that the depressant effect of d-amphetamine on these cells is mediated through a striato-nigral neuronal feedback loop.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)