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Science 23 April 1976:
Vol. 192. no. 4237, pp. 385 - 387
DOI: 10.1126/science.1257774
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Articles

Science, Vol 192, Issue 4237, 385-387
Copyright © 1976 by American Association for the Advancement of Science

articles

Hyperphagia and increased growth in rats after intraventricular injection of 5,7-dihydroxytryptamine

CF Saller and EM Stricker

Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86% depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5-hydroxytryptamine when the pretreatment was withheld, perhaps because substantial depletions of norepinephrine occurred as well.


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